There were wins for Hemel, Derby, Newcastle, Worthing, Loughborough and Bradford, with the Yorkshire side providing the only upset across the six fixtures.
We take a look at all the weekend's matchups below, with each heading clickable for live stats, plus links to live stats and live streams at the bottom of the page.
Hemel moved into next weekend's quarter-finals following a straightforward 101-68 victory over Nottingham Hoods.
Storm dominated D1M's basement side to lead 52-28 by the half, further stretching their advantage as the game wore on.
Jack Burnell led the way for the hosts with 22 points as he went 6-13 from deep, whilst Mike Williams (18pts) and Greg Poleon (18pts, 17reb, 7ast) also impressed.
Matt Ward-Hibbert top scored for Nottingham with 20 points, but it's Hemel that move on to face Bradford in the next round.
Jack Burnell is 5-6 from deep, including this one from miles— bbl fix (@BblFix) April 24, 2021
🎥 Storm pic.twitter.com/cMR5f4cNJY
Joshua Guddemi, Malcolm Smith and Jacob Conway all passed 20 points as Derby eased past Oaklands Wolves 105-77.
The forwards all helped the hosts to build a double digit lead midway through the second quarter, with the Trailblazers' advantage never dropping below that point the rest of the way.
AJ Roberts' double-double of 21 points and 12 rebounds was the standout performance for the Wolves, but the difference between the two sides still touched 30 points before the game was out.
Derby now host #5 seed Newcastle in what is sure to be an exciting contest between two sides that split their regular season games 1-1.
Newcastle made it three wins out of three against Leicester this season, beating the Warriors 87-77 to dump the Midlands' side out of the playoffs.
After a relatively even first quarter, the hosts went on a 13-0 run that broke the game open and provided Newcastle with a lead they'd never relinquish.
Ronald Blain continued his good form this season to lead Newcastle with 26 points, adding 11 rebounds and five assists for good measure. Support was provided by David Moya and Brandon Federici, who added 16 and 13 points respectively.
Leon Henry's 26 points paced the Warriors as NBL scoring champ Mo Williams put up a 19 point, 12 rebound double-double.
In the only upset of the round by a lower seed team, Bradford went to Essex and knocked off the Rebels by the narrowest of margins.
In a back and forth affair that neither side led by more than six points, Andreas Lycoudis' clutch triple with 47 seconds remaining proved to be the winning basket.
The game looked like it would swing back in the host's favour as Lycoudis was assessed with a costly technical foul on an inbounds play shortly after handing the Dragons the lead.
Essex would miss the resulting free throw however, before turning the ball over on their next possession. Tom Child and Rory Winter would both have further efforts to steal the win, but neither shot would drop as Bradford were left to celebrate a famous victory.
Jermayne Laing and Rihards Sulcs both had 16 points for the visitors, as Jordan Gray led all scorers for Essex with 18.
A 17-point, 20-rebound double-double from Max Richardson helped #7 seed Worthing top BA London Lions 89-83.
As two well-matched teams that split their regular season ties, Thunder saw Richardson, Zaire Taylor (23pts), Ishmael Fontaine (20pts), Howard Crawford (14pts, 13reb) and Tom Ward (12pts, 7reb.7ast) in double-digits scoring, dishing 24 assists in the process.
Despite trailing by 16 points shortly before half time, Barking fought back after the break but couldn't find the telling basket to get back on level terms.
Jase Harrison and Abiodun Adedo both dropped 21 points for the visitors as Worthing now move on to face #2 seed Thames Valley.
Loughborough grabbed a 75-68 win over Reading on Saturday afternoon, securing a road trip to Solent in the process.
Despite a daunting assignment in the next round, Loughborough will no doubt be buoyed by a 21 point, 12 assist, eight rebound effort from guard Kyle Jimenez and 16 points from Jonas Dieterich.
The early stages of this one belonged to the visitors, with Reading taking the opening frame 19-10. The Riders would fight back and claim the second period 28-16 and the third 24-14 to lead by double digits going into the final 10 minutes.
The Rockets would make an attempt at getting back into the game behind Samuel Toluwase's 21-point, 10-rebound double-double, but it wouldn't be enough on an afternoon when the visitors went just 3/22 from beyond the arc.
2:30pm - #8 Loughborough Riders 75-68 #9 Reading Rockets - LIVE STATS/LIVE STREAM
4pm - #5 Team Newcastle University 87-77 #12 Leicester Warriors - LIVE STATS/LIVE STREAM LOCATION
5pm - #3 Hemel Storm 101-68 #14 Nottingham Hoods - LIVE STREAM/LIVE STREAM LOCATION
1pm - #6 Essex Rebels 73-74 #11 Bradford Dragons - LIVE STATS/LIVE STREAM
5pm - #7 Worthing Thunder 89-83 #10 BA London Lions - LIVE STATS/LIVE STREAM LOCATION
5:30pm - #4 Derby Trailblazers 105-77 #13 Oaklands Wolves - LIVE STATS/LIVE STREAM
Main image credit - Luke Simcock