League leaders Ipswich head to COLA to finish the weekend, providing a fitting end to the trio of games.
Saturday's action involves Loughborough Riders hosting Reading, and Worcester facing off against BA London Lions II.
You can find a preview on all three games below, plus live stats and a live streaming info as well.
Unbeaten league leaders Ipswich face another road test this weekend as they head to London to take on a familiar foe.
Well known to each other from junior contests as well as WEABL battles, these two sides will be going all out for a win that would provide some serious momentum to the victor.
Both teams come into this one in good form. Ipswich remain perfect on the season following a 92-79 victory in Nottingham, while COLA also won last weekend, easing past Barking 77-51.
These two sides also contributed three players to last week's FocusHoops Team of the Week, with Cameron Taylor-Willis unlucky to not make it four.
A key to this one could well be if Southwark can find a way to slow down Ipswich's offensive might, with both Harriet Welham (25.7ppg, 10.7rpg, 7.3apg) and Esther Little (18.3ppg, 20rpg, 6apg) looking very imposing at present. A question mark does remain over Little's health though, the young shooter appeared to hurt an ankle at the end of the Nottingham game and could be a doubt for the contest.
Southwark do have a match winner of their own in the shape of Simona Henshaw (13ppg, 8rpg, 46.7 3pt%) though, the young guard has been in fine form so far this season.
"We're looking forward to testing ourselves again in our fourth game of the season, trying to build on our performance last week," said Southwark head coach Jackson Gibbons.
"Ipswich are the hot team in the league right now so it will be a good experience for our group."
Ipswich head coach Nick Drane added: "We are looking forward to the match up with COLA. They have made a great start to the season and I believe they will be one of the most dangerous teams this year.
"COLA have been arguably the best programme around D1, the WEABL and U18 Jnr. NBL over the last four or five seasons so are always a favourite for the championship.
"Despite our good start to the season, we see this as a very even match up and we will need to be ready."
After an opening weekend win, Worcester have had to wait the best part of a month to get another taste of D1W action as they look to move to 2-0.
Saturday's opponents Barking have struggled in all three of their games this season and a road trip to a Wolves team that looked good in their 68-58 win against Bristol may result in another long afternoon.
Worcester's Shanice Turner put in a Player of the Week performance during the season opener, she'll be hoping the lay off hasn't slowed her momentum, whilst the Lions will no doubt turn to Kian Omer-Jones, Leia Edwards and Paula Puzule as they try to turn things around.
"I am incredibly excited for the game this weekend, we have been waiting a while for our next game and my team can’t wait to get on the floor and compete," said Wolves head coach Ryan Emery.
Two sides who couldn't start their season with a win meet on Saturday afternoon as both Loughborough and Reading try to get back to 1-1.
The Riders began their campaign with a 98-83 defeat against a strong looking Solent outfit, whereas Reading haven't played since they lost out 72-52 to COLA Southwark Pride on the opening weekend of the season.
With little to go on in terms of form, last season's results could provide the most accurate yardstick for this one. The Rockets handled Loughborough twice in 2019/20 by a combined margin of 56 points across the two games.
If these sides remain close to what they were a year ago though remains to be seen.
4pm - Loughborough Riders v Reading Rockets - LIVE STATS
Main image credit - Nick Winter