Twenty nine ties will be played in total, with all but one of them scheduled in for Sunday. That leaves London Greenhouse Pioneers and Hackey Jedis to lock horns on Monday night in an all-London affair to wrap up the round.
The next stage is scheduled for two week's time, 22/23 October, but D1M teams don't enter the draw until the following round in November.
All the teams will be battling it out for a place in January's final at the National Basketball Performance Centre in Manchester, set to take place across the weekend of 21/22 January 2023.
The second round marks the entry point into the competition for D2 sides, making for some highly-anticipated ties this weekend.
D2 South side Greenwich Titans enjoyed a big win last weekend to take them top of the standings. They've got a derby clash with local rivals London Westside, who were relegated from D2 at the end of last season.
Doncaster Eagles made it to the semi-finals of last year's playoffs before dipping out to eventual winners Manchester. They'll have a home tie on Sunday against fellow D2 side Worcester Wolves.
London Elite made it to round four of the Cup last year as a D3 outfit. Now promoted to D2, they'll have a road test against London Warriors, whilst much-fancied D3 side Milton Keynes will try to keep their Cup hopes alive away to a City of Birmingham Rockets team that won their D2 North opener 103-49 last weekend.
There's more Cup basketball on the horizon in the coming weeks with other competitions set to continue.
The next round of the Women's National Cup is in two week's time, 23/24 October, that includes an opening clash for current holders Stockport Lapwings.
The Sure Shot U18 and U16 competitions all go once again next weekend, 15/16 October, for both the girls and boys. With over 75 fixtures scheduled to take place across the two days, it's sure to make for a thrilling weekend.
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