A pair of dubs against Worcester means that CoLA now just a few results away from sealing top spot and what would be their first top-flight league title since D1W was split into three regional conferences in 2015/16.
There were also some important results at the other end of the standings this weekend, including London's huge 60-49 win over Reading Rockets.
There's a recap of all the weekend's action below, and each result is also clickable if you wish to view the live stats.
London Lions II climbed out of the relegation places for the first time since before the mid-season break in December as they beat relegation rivals Reading 60-49.
London wing Fatmata Janneh was once again in top form, closing with a stunning 28 points to go with 15 rebounds to form a sizable double-double.
Playing without Ruchae Walton, Janneh's contribution was even more telling in a low-scoring contest where Grace Strickland (11pts, 3reb, 3ast) was the only other Lion into double digits scoring.
Gaila Comesana (14pts, 13reb), Jessie Ford (14pts, 5reb) and Candela Hermida Nunez (13pts, 7ast) all played well for the hosts, though no other player passed three points.
The loss now drags Reading into the bottom two, though London and Worcester are only three points ahead as things stand.
Lions II pick up an important win at Reading.— bbl fix (@BblFix) March 6, 2022
📸 Luke Simcock pic.twitter.com/AVn187r3cX
Bristol Flyers (9-11) made it four wins from their last five games as they beat Nottingham Trent University (1-17) 59-54, relegating NTU in the process.
Promoted to the top flight following the 2018/19 season, it sends Nottingham back down following a tough campaign in which they've lost seven of their 17 games by 10 points or less.
Bristol's Emma Bailey played a good game in this one, her 10 points went with eight rebounds and five assists.
Loughborough Riders (13-4) and Ipswich (11-6) put on one of the shows of the weekend as the Suffolk side grabbed a stunning 68-65 win.
The result all but ends any real competition in the D1W title race, which will be zero concern to Ipswich as they took another step towards a top-four finish.
Olivia Forster was a standout for the hosts, she had 27 points to counter Loughborough's Alia El Shabrawy (21pts, 9reb).
Player Spotlight, WNBL D1 (🏴) edition.— 🌾🌾 (@Julien_Korver26) March 6, 2022
Let me introduce you some (young) talent from England. Meet Olivia Forster (@OliviaForster13) from @IpswichBball (Class of 2023).
27 points, 3 assists and 2 rebounds vs Loughborough.
13.1 points, 2.5 assists, 2.1 rebounds this season.
Thames Valley Cavaliers (13-4) and Anglia Ruskin University (10-6) play twice in two days, with no change in the outcome across the weekend.
TVC took Saturday's home clash 62-51 thanks to a 16-point, 10-rebound double-double from Kat Goldsby before a 61-55 victory 24 hours later.
Likewise, CoLA Southwark Pride (17-1) enjoyed a pair of wins against the same opponent as they saw off Worcester Wolves (5-12) twice.
Saturday's 74-55 W came courtesy of 18 points and 13 boards from Player of the Year candidate Isi Ozzy-Momodu, with the CoLA forward following that performance up with 12 points and six rebounds on Sunday as Pride won 94-59.
Sunday's only other tie saw Cardiff Met Archers II (8-9) beating Team Solent Kestrels (9-8) 93-65.
Amber Deane and Denisa Molnar had 22 points apiece for the hosts, with Faye Endean leading the way for Solent, she had 20.
1pm - Bristol Flyers 59-54 Nottingham Trent University - LIVE STATS
3pm - Thames Valley Cavaliers 62-51 Anglia Ruskin University - LIVE STATS
4pm - Worcester Wolves 55-74 CoLA Southwark Pride - LIVE STATS
2:15pm - CoLA Southwark Pride 94-59 Worcester Wolves - LIVE STATS
3pm - Anglia Ruskin University 55-61 Thames Valley Cavaliers
3:15pm - Cardiff Met Archers II 93-65 Team Solent Kestrels
5:45pm - Reading Rockets 49-60 London Lions II - LIVE STATS
Main image credit - Luke Simcock