There's a top-of-the-table clash between two teams in the top four, while second takes a trip to fifth during a weekend that could shake up the D1W standings.
The NBL Live cameras will also be on hand to cover tomorrow's clash between Solent and Worcester, live on the BE YouTube channel.
We take a look at all the action below, with links to live stats and live streams at the bottom of the page.
Top travels to fourth tomorrow as Loughborough entertain leaders CoLA Southwark Pride.
In what is a repeat of the WNBL National Cup tie from a few weeks ago, the Riders will be looking for some revenge as CoLA took that contest 62-60.
Loughborough did lead that game 50-45 going into the final quarter, showing they can keep up with the unbeaten league leaders on their day.
There's sure to be a premium on points in this one, with both teams amongst the league's best for defence this season.
Loughborough's 55.7PPG against is trumped only by CoLA, who's 48.1PPG against is the best in the division.
Team Solent Kestrels (3-5) have lost four in a row but will try to use the excitement of the NBL Live cameras to boost their fortunes this weekend.
The Kestrels host Worcester Wolves (4-3) who are also in the mix for a playoff spot but haven't played since 21 November.
Coverage gets underway at 2:50pm and tip is at 3:30pm, with commentary from John Hobbs and Mark Jackson.
Anglia Ruskin University (4-2) had to tough it out last weekend to seal their fourth win of the season, narrowly edging London Lions II, but it does mean ARU have won four of their last five as a team in form.
Ipswich (5-1) and reigning Player of the Week Ava Battese will be a tough test tomorrow though. The battle down low between two of the league's best forwards in Cameron Taylor-Willis and Kat Hulme is sure to also make for great viewing.
Cardiff Met Archers II (4-4) will try to build on their statement win on the road in Solent last time out, as they take a trip along the M4 to play Bristol Flyers (3-5).
Sat just outside the playoffs in ninth, the Flyers can make it three wins in a row tomorrow, jumping into the thick of the post-season race in the process.
In Sunday's only contest, Reading Rockets (2-5) begin a three-game home stand as they welcome Nottingham Trent University (0-8).
With NTU currently bottom in 12th and 11th-placed London Lions II without a game, the Rockets can begin to pull clear of D1W's relegation places with a victory here.
For NTU, they'd love to pick up their first of the season before 2021 is in the books.
4pm - Anglia Ruskin University v Ipswich - LIVE STATS
5pm - Bristol Flyers v Cardiff Met Archers II - LIVE STATS
4pm - Reading Rockets v Nottingham Trent University - LIVE STATS
Main image credit - Loughborough basketball