Unbeaten sides Loughborough and Solent clash, whilst reigning champs Ipswich are at home to Nottingham and there's a London derby between Lions II and CoLA Southwark Pride.
We take a look at all the action below, with links to live stats and live streams at the bottom of the page.
Two spotless records enter but only one can remain as Loughborough host Solent tomorrow.
Wins against Cardiff, Worcester and Bristol have vaulted the Riders to a share of top spot in the D1W standings, with CoLA Southwark Pride the only other team sat at 3-0.
Captain Robyn Ainge earned a spot in the FocusHoops's Team of the Week for her performance against the Flyers, enjoying a well-rounded 15 points, five rebounds, three assists and five steals. Teammates Sasha Lecuyer and Alia El Shabrawy have both earned weekly honours this year as well.
Solent are also yet to taste defeat this season, but a weekend off means the Kestrels have only faced the two opponents in London Lions II and Bristol Flyers.
American forward Molly Danielson (17.0ppg, 9.0rpg), Faye Endean (13.5ppg, 5.5rpg) and Lauren Dabbs (14.5ppg, 3.5rpg, 3.5apg) have all started the new campaign in good form and should make up the bulk of Solent's offence tomorrow.
Worcester Wolves (2-1) grabbed a gutsy road win last weekend in Reading and they now head home to host Anglia Ruskin University (1-1).
Ruskin picked up their first win of the season last time out, knocking off Cardiff 60-50 thanks to the antics of Player of the Week Katrin Hulme. ARU will no doubt be hoping for more of the same from their talisman tomorrow.
There's a London derby to look forward to as joint-leaders CoLA Southwark Pride (3-0) head across the Capital to take on London Lions II (1-2).
These teams met three times last season, with CoLA taking all three contests. The two leagues games went to coach Gibbons' team by an average of 23 points before the eventual playoff finalists won 68-45 in their post-season meeting.
It's also worth noting that CoLA's traditionally stingy defence has been in full effect this season already, with no opponent scoring more than 57 points in three games to date. Expect that run to continue tomorrow.
Ipswich (2-0) put their unbeaten record on the line tomorrow as they entertain winless Nottingham Trent University (0-2).
It's not been the start to the season they hoped for but NTU did show signs of life last weekend after a heavy 43-point loss in their home opener. Lilly Annim (14pts, 9reb) and Lindsey Cleary (15pts) both played well in the 61-49 loss to London Lions II.
Ipswich will no doubt lean on Cameron Taylor-Willis (12.0ppg, 17.0rpg) as she looks to cause her usual problems around the basket at both ends of the floor.
The only other game in D1W this weekend sees Bristol Flyers (0-3) take a trip east to face Reading Rockets (0-3).
After three games apiece without a win, both these sides will be itching to get off the mark and kick star their campaign before any more ground is lost to the teams ahead.
Eva Luzon was a perfect 8-8 off the bench for Reading last weekend and will be pushing for a greater role in the Rockets' game plan, whilst Bristol will be searching for an improved offensive performance after being held to 16 first-half points by Loughborough a week ago.
3:30pm - Ipswich v Nottingham Trent University - LIVE STATS
4pm - Worcester Wolves v Anglia Ruskin University - LIVE STATS
Main image credit - Luke Simcock