Only co-leaders Loughborough plus Anglia Ruskin are without a game in week six, meaning that CoLA Southwark Pride can assume top spot if they can beat Nottingham Trent University.
We take a look at all the action below, with links to live stats and live streams at the bottom of the page.
Two teams that could desperately use a kick-start to their early season form, Worcester travel to London tomorrow to face the Lions.
The hosts lost in Cardiff last weekend, making it back-to-back defeats after coming up second best to fellow Londoners CoLA two weeks ago.
Likewise, the early going has also been a struggle for the Wolves as they've dropped three of their last four games, including a 64-55 home defeat by Thames Valley last weekend.
Despite recent form, London's Fatmata Janneh currently ranks second in D1W with 20.6PPG, she will be key for the hosts in this one.
Worcester will no doubt turn to Chandre Nunez and her team-high 15.0ppg. Her battle with Janneh will be one to watch tomorrow.
Bristol Flyers (1-4) used an NBL Live performance to seal their first win of the season last weekend, beating Anglia Ruskin. The South West side will look to make it two in a row tomorrow as they host Thames Valley Cavaliers (2-2).
CoLA Southwark Pride (5-0) can move into sole possession of top spot in D1W this weekend if they can rise to see off Nottingham Trent University (0-4).
Still without a win to their name, NTU have been edging closer to success in recent weeks. The play of American guard Lindsey Cleary saw her make another Team of the Week last time out, though pushing her team to victory in London tomorrow will be a tall order.
0-3 on the road this season, Reading Rockets (1-4) will be delighted to be heading back to Berkshire tomorrow to begin a two game home stand, starting with a visit from Team Solent Kestrels (3-1).
Solent look a strong team this year and should fancy their chances against the out of form Rockets, even if the game is being played in enemy territory.
Finally, Ipswich (3-1) will have an opportunity to bounce back to winning ways as they welcome Cardiff Met Archers II (2-2) to Copleston.
After three straight victories to begin the year, the reigning champs came unstuck in CoLA last time out. That'll be something that Cardiff's Isobel Bunyan (D1W 2nd best efficiency) and Carys Roy (D1W 5th best efficiency) look to exploit tomorrow.
1pm - Bristol Flyers v Thames Valley Cavaliers - LIVE STATS
2pm - London Lions II v Worcester Wolves - LIVE STATS
2:15pm - CoLA Southwark Pride v Nottingham Trent University - LIVE STATS
3:30pm - Ipswich v Cardiff Met Archers II - LIVE STATS
Main image credit - Luke Simcock